Chronic anal fissure CAF is a linear split of the anoderm. However, the exact efficient dose of BT, number of injections per session and the injection sites are still debatable. The aim of this analysis was to assess the dose-dependent efficiency of botulinum toxin injection for CAF. A total of patients from 34 prospective studies used either Botox or Dysport formulations were qualified for this meta-analysis. Moreover, there were no BT dose-dependent postoperative complications or fecal incontinence and significant difference in healing rates compared BT injection into the anal sphincter muscles.
A fissure is a split in the skin of the anal canal. This split fails to heal and becomes established as a painful ulcer associated with spasm of the anal sphincter muscle. Most anal fissures arise following trauma injury to the anus. The commonest trauma is that occasioned by the passage of a hard, constipated stool. However, anal fissures can occur following bouts of diarrhoea, childbirth etc. An anal fissure is a simple mechanical problem and does not "turn to cancer".
Try out PMC Labs and tell us what you think. Learn More. To evaluate the effectiveness of Botulinum toxin injection in the treatment of anal fissure.
Injections of botulinum toxin Botox may help heal a tear fissure in the anus. The internal anal sphincter, one of two muscles that control the anus, is always under tension. If this tension also called resting pressure is too high, spasms and reduced blood flow can cause an anal fissure or prevent an existing one from healing.