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Introduction: Basal-bolus BB regimens are generally used to intensify basal insulin therapy in patients with type 2 diabetes T2D not meeting glycemic targets. However, drawbacks include multiple injection burden and risk of weight gain and hypoglycemia. We compared these treatments in a post hoc propensity score matched analysis using randomized trial data. Methods: From the LixiLan-L study, patients who had been randomized to iGlarLixi were matched for age, sex, race, T2D duration, baseline body mass index, glycated hemoglobin HbA1c , fasting plasma glucose, insulin dose, and metformin use to patients who had been randomized to a BB regimen in the GetGoal Duo-2 trial. Results: At study end, estimated treatment differences for reduction in HbA1c and weight change, and ratio of hypoglycemia events per patient-year BB vs iGlarLixi were - 0.
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